PRÉFACE – Abstracta Iranica 30 – 2007

Access published March 30 , 2007

Biol. Pharm. Bull. 30(11) 2007—2011 (2007)

skin and hair, and is synthesized in melanosomes transferred from melanocytes. Although melanin plays an important protective role against UV light, over production and accumulation of melanin pigment it could create serious skin problems such as freckles, age spots, and melasma. Thus, the inhibition of melanogenesis has been the focus of medicinal and cosmetic treatments for skin depigmenting ...

Statement Erin Munro November 30 , 2007

A gap junction is a perforation connecting the cytoplasms of two neurons so that ions flow freely from one to the other. Thus when one neuron fires, it may induce its electrically coupled neighbors to fire. There is increasing evidence that gap junctions among pyramidal cell axons play a role in oscillations. The gamma oscillations (30-80 Hz) seen in hippocampal experiments in [8, 9] and models...

Drug Safety 2007; 30 (6): 515-525

Monitoring (Uppsala Monitoring Centre [UMC]) has received many individual case safety reports (ICSRs) associating HMG-CoA reductase inhibitor drug (statin) use with the occurrence of muscle damage, including rhabdomyolysis, and also peripheral neuropathy. A new signal has now appeared of disproportionally high reporting of upper motor neurone lesions. Aim and Scope: The aim of this paper is to ...

Drug Safety 2007; 30 (7): 623-625

A Bayesian confidence propagation neural network (BCPNN)-based technique Abstract has been in routine use for data mining the 3 million suspected adverse drug reactions (ADRs) in the WHO database of suspected ADRs of as part of the signal-detection process since 1998. Data mining is used to enhance the early detection of previously unknown possible drug-ADR relationships, by highlighting combin...